Lung Cancer Practice Test

These questions are part of the practice quiz. Start practicing

• What are the two broad groups of lung cancer?
• Which biomarker is commonly expressed in the histology of small cell lung cancer as part of its neuroendocrine profile?
• Which imaging and morphological features suggest malignancy in a pulmonary nodule?
• Which imaging modality provides metabolic information for staging in NSCLC?
• Squamous cell carcinoma more commonly presents with what symptom?
• What increases the likelihood of malignancy?
• What does the TNM staging system evaluate in NSCLC?
• What is the management for solid nodules >8 mm with intermediate suspicion for cancer?
• Which statement is true about NSCLC and SCLC?
• A common chemotherapy regimen used for SCLC?
• Is surgical resection usually an option for SCLC?
• What is the minimum pack-year smoking history and smoking status required for high-risk lung cancer screening?
• Squamous cell lung cancer features mutations in CDKN2A and which other gene?
• What adjuvant targeted therapy is approved for resected EGFR-mutant NSCLC and improves disease-free survival?
• For NSCLC, which stage groups are typically treated with surgical resection with curative intent?
• Which group has rapid doubling time and very aggressive?
• How does bronchioalveolar cell carcinoma spread and invade?
• In limited-stage Small Cell Lung Cancer, radiotherapy is typically given concurrently with chemotherapy. True or False?
• Which factor influences prognosis in lung cancer?
• What defines extensive disease in SCLC staging?
• Where do pulmonary carcinoid tumors typically grow?
• Which of the following is NOT a common adverse effect of PD-1/PD-L1 inhibitors?
• How does smoking cessation affect prognosis during lung cancer treatment?
• ALK rearrangements in NSCLC are targeted by which class of drugs?
• What is tumor mutational burden (TMB) and its potential role in NSCLC?
• In tobacco cessation or chemoprevention to promote repair, which initial strategies are described?
• Why is performance status important in lung cancer treatment decisions?
• In palliative treatment, brachytherapy is used to debulk central tumors to relieve bronchial obstruction.
• What are some other common manifestations of lung cancer?
• Which is an example of switch maintenance after first-line NSCLC chemotherapy?
• Which tumor type is described as well-differentiated neuroendocrine tumors that are pedunculated growths within the central bronchi and account for about 1-2% of lung cancers?
• What imaging is used for annual lung cancer screening in high-risk patients?
• The ADAURA trial demonstrated that adjuvant Osimertinib improves which outcome in resected EGFR-mutant NSCLC?
• Which biomarker is used to select patients for pembrolizumab monotherapy in NSCLC?
• Which sequence describes the described approach to tobacco cessation or chemoprevention to promote repair?
• What is the role of radiation therapy in oligometastatic NSCLC?
• What is the typical duration for maintenance chemotherapy to help improve survival rates?
• In first-line NSCLC therapy, pembrolizumab monotherapy is primarily used for tumors with what PD-L1 expression level?
• BRAF V600E mutation in NSCLC is targeted with which combination therapy?
• What constitutes a complete radiographic response to therapy in lung cancer?
• What CT features are typical of adenocarcinoma of the lung?
• What is prophylactic cranial irradiation (PCI) and when is it used?
• Which serum markers are associated with prognosis in lung cancer?
• Which procedure uses a fiberoptic bronchoscope to view the airways and obtain samples?
• Which histologic features are characteristic of lung adenocarcinoma?
• At what stages are NSCLC patients not surgical candidates?
• Which rare germline mutation is associated with never-smokers?
• In the described cancer progression, which hallmark is associated with progression?
• NTRK fusions in NSCLC are targeted with which inhibitors?
• What lab and imaging workup is used in lung cancer staging?
• Which feature is NOT part of Horner syndrome?
• Which findings are commonly associated with paraneoplastic syndromes in SCLC?
• What is a classic anatomical description of carcinoid tumors?
• Which drug is commonly used as maintenance therapy in non-squamous NSCLC?
• In confirming NSCLC, which tests are routinely performed alongside histology to subtype and identify driver mutations?
• In NSCLC TNM staging, which statement is true?
• Stage IV NSCLC is typically treated with which combination?
• What is the management for solid nodules >8 mm with low suspicion for cancer?
• Where does squamous cell carcinoma arise and how does it spread?
• Stopping smoking reduces lung cancer risk by what percentage compared with continuing to smoke?
• In squamous cell lung cancer, CDKN2A mutation is accompanied by mutation in which gene?
• What percentage of lung cancers are pulmonary carcinoid tumors?
• ROS1 rearrangements in NSCLC are targeted by which inhibitors?
• Which histologic features best describe small cell lung cancer?
• Which statement best contrasts NSCLC and SCLC?
• What percentage of SCLC patients have extensive disease?
• What is the prognosis for untreated small cell lung cancer (SCLC)?
• What is the median survival for limited stage versus extensive stage SCLC?
• What is the 5-year survival rate after surgical removal of typical pulmonary carcinoid tumors?
• Which agents specifically target KRAS G12C mutations in NSCLC?
• Which agents are used for ROS1-rearranged NSCLC?
• Which statement best describes osimertinib in EGFR-mutant NSCLC?
• Video-assisted thoracoscopic surgery (VATS) is commonly used in lung cancer for what purpose?
• Which sequence best describes the pathogenesis of the progression of lung cancer due to carcinogens?
• What is the most common type of NSCLC and the most frequent pulmonary carcinoma in non-smokers?
• Which of the following is NOT listed as a clinical predictor for lung cancer prognosis?
• What is the best initial treatment approach for typical pulmonary carcinoid tumors?
• Which of the following is NOT a typical sign of malignancy in a pulmonary nodule?
• What is the age range recommended for annual low-dose CT lung cancer screening in high-risk individuals?
• What term describes rare remote effects triggered by an abnormal immune response to a neoplasm, more common in SCLC?
• In the TNM staging system for NSCLC, which statement about the components is true?
• When is neoadjuvant chemotherapy usually reserved in NSCLC?
• Hypercalcemia in paraneoplastic syndromes is due to production of which substance by the tumor?
• In lung cancer staging, which stage indicates the most advanced disease with the worst prognosis?
• Which histology is most strongly associated with smoking and tends to be central?
• ALK inhibitors are used in NSCLC for tumors with ALK rearrangements. Which statement is true?
• What histologic feature is associated with large cell carcinoma of the lung?
• What is the management for solid nodules >8 mm with high suspicion for cancer?
• Which is a common adverse effect of PD-1/PD-L1 inhibitors?
• Which paraneoplastic syndromes are classically associated with SCLC?
• Which statement best describes growth and metastasis patterns between SCLC and NSCLC?
• Which of the following is NOT listed as a common secondary environmental risk factor for lung cancer?
• Which cancer type accounts for about 85% of lung cancers?
• Name a CNS-penetrant EGFR-TKI used to treat brain metastases in EGFR-mutant NSCLC.
• Adenocarcinomas feature mutations activating which signaling pathway?
• What defines limited disease in SCLC staging?
• What symptom is unique or additional in bronchioalveolar cell carcinoma presentation?
• Which tumor type was historically used to describe a subset now categorized as invasive mucinous adenocarcinoma and lepidic predominant nonmucinous adenocarcinoma?
• Where does lung cancer rank in cancer commonality?
• Which stage groups are treated with surgical resection, chemotherapy, plus radiation?
• In SCLC, radiation with chemotherapy improves survival.
• How would you summarize prognosis for stage IV NSCLC?
• Platinum-based regimens help improve survival in patients with which stage?
• Which of the following is a common site of metastasis for lung cancer?
• How does PET-CT contribute to staging of lung cancer?
• Which statement best describes prognosis by stage?
• Which NSCLC stage is commonly treated with a combination of surgery, chemotherapy, and radiation?
• Which factor demonstrates a clear dose-dependent relationship with lung cancer risk?
• When does recurrence typically present after chemotherapy in SCLC?
• What is the typical management for typical pulmonary carcinoid tumors?
• Which statement about brain metastases in NSCLC is true?
• When is adjuvant chemotherapy administered?
• Which of the following is NOT a common site of metastasis for lung cancer?
• What imaging finding is associated with small cell lung cancer?
• What is the goal of maintenance therapy in NSCLC?
• What is the treatment intent for limited stage versus extensive stage SCLC?
• In SCLC, extensive stage corresponds to which stage classifications?
• Maintenance chemotherapy goal in SCLC?
• Which drug is a KRAS G12C inhibitor?
• In TNM staging for lung cancer, which option best describes the components?
• Why are brain imaging and CNS penetration important in NSCLC therapy selection?
• A PET scan is helpful in finding distant metastases but what is a major drawback?
• What is the role of liquid biopsy in lung cancer management?
• In stage IV NSCLC, prognosis is strongly influenced by what factors?
• Pulmonary carcinoid tumors are classified as which of the following?
• Performance status is a key prognostic factor in lung cancer. True or False?
• Tobacco smoke is a major risk factor for lung cancer with a clear dose-dependent relationship.
• MET exon 14 skipping mutations in Non-Small Cell Lung Cancer are targeted with which class of therapy?
• Which type of lung cancer is also known as oat cell carcinoma?
• What is radiation pneumonitis and how is it managed?
• Which histologic type of NSCLC is commonly peripheral?
• TPS in PD-L1 testing stands for which of the following?
• Non-small cell lung cancer comprises three main subtypes in order of prevalence from most to least common. Which order is correct?
• Which statement about pulmonary carcinoid tumors is true?
• What are the clinical signs of Horner syndrome?
• Which of the following lists the common distant metastasis sites for lung cancer?
• Which of the following may be an incidental finding in pulmonary carcinoid tumors?
• Which paraneoplastic syndrome increases the risk for DVT/PE and can present with Trousseau sign of malignancy?
• Which is a common adverse effect of platinum-based chemotherapy?
• What is the role of molecular driver status in treatment planning?
• Which cancer infiltrates the mucosal layer causing bronchial obstruction?
• Which of the following is NOT an actionable driver alteration tested in NSCLC?
• Which statement about pulmonary carcinoid tumors is accurate?
• A malignant pleural effusion in non-small cell lung cancer upstages the disease to which category?
• In small cell lung cancer, SIADH leads to which electrolyte disturbance?
• Name an immune checkpoint inhibitor approved for NSCLC.
• What imaging findings are associated with SCLC?
• Stage IV NSCLC is typically treated with chemotherapy and what else?
• Which histologic feature is characteristic of squamous cell carcinoma of the lung?
• What percentage of lung cancers are caused by cigarette smoking?
• Lambert-Eaton myasthenic syndrome is a paraneoplastic syndrome associated with which cancer?
• What is the role of maintenance therapy after first-line chemotherapy in NSCLC?
• Eligibility for high-risk lung cancer screening includes which of the following?
• What is the standard first-line chemotherapy regimen for Limited-Stage Small Cell Lung Cancer?
• What percentage of SCLC patients present with limited disease?
• Where does adenocarcinoma arise in the lungs?
• Which of the following best describes how TMB is used in NSCLC?
• Which list comprises key clinical manifestations associated with lung cancer?
• Which lung cancer type accounts for about 14% of cases and is often more aggressive and diagnosed after metastasis?
• What biopsy modality is commonly used to obtain tissue from a central lung lesion for diagnosis?
• Which imaging modality is most useful to identify metabolically active nodes for staging and biopsy planning in lung cancer?
• What is the treatment for Stage II and a subset of Stage IB NSCLC?
• Which histologic subtype is most strongly associated with smoking?
• How is immune-related pneumonitis managed?
• Which organ is NOT a commonly cited site of distant metastasis for lung cancer?
• Mechanism of action of Etoposide?
• How are EGFR-mutant NSCLC and brain metastases best managed?
• Which combination of symptoms is associated with carcinoid syndrome?
• Which statement about malignant features in a pulmonary nodule is true?
• What is SBRT and when is it typically used in lung cancer?
• What is the significance of malignant pleural effusion in lung cancer staging?
• Which procedure is commonly used to obtain pleural fluid for cytology in suspected lung cancer?
• Which therapy is typically used to relieve bronchial obstruction due to central tumors in SCLC?
• Which first-line therapy is preferred for EGFR-mutant NSCLC with brain metastases?
• Fine needle aspiration of supraclavicular or cervical lymph nodes is mostly used for what purpose?
• What causes Horner syndrome in lung cancer patients?
• Which are common adverse effects of EGFR inhibitors?
• Which drug is commonly paired with etoposide in SCLC regimens?
• Inherited mutations in which gene are linked to genetic predisposition in lung cancer?
• What is the treatment approach for Stage I and Stage II NSCLC?
• Lung cancer is the leading cause of cancer-related mortality regardless of gender.
• What effect do thick cavitary walls have on the risk of malignancy?
• In squamous cell lung cancer, CDKN2A mutation is commonly accompanied by mutation in which gene?
• In standard staging workup for lung cancer, which brain imaging modality is included?
• Squamous cell carcinoma typically arises in bronchial areas and presents with which symptom?
• Crizotinib is a targeted therapy that inhibits which alterations in NSCLC?
• In platinum-based doublet chemotherapy for NSCLC, which platinum agents are commonly used?
• Which term corresponds to bronchioalveolar cell carcinoma in older nomenclature before reclassification into invasive mucinous and lepidic predominant nonmucinous adenocarcinomas?
• What is the typical first-line systemic therapy backbone for advanced NSCLC without driver mutations?
• MET exon 14 skipping in NSCLC is targeted by which class of inhibitors?
• What are the purposes of lung cancer staging?
• Why is chest X-ray not recommended for lung cancer screening?
• Which of the following is NOT listed as a common secondary environmental risk factor for lung cancer?
• Which two broad groups comprise lung cancer classification?
• What is the standard diagnostic approach to confirm NSCLC histology and driver mutations?